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Created by:Brian FreitagBrian Freitag
{"id":475822,"type":0,"block_id":"b_ri96_1357425334","theme_id":21,"user_id":172113,"path":"Rube-Goldberg-in-the-Blood","title":"Rube Goldberg in the Blood","pubtitle":"Rube Goldberg in the Blood","tags":"","public":true,"publicAccess":true,"private_link_enabled":0,"thumb":"https://s3-eu-west-1.amazonaws.com/infogram-thumbs-200/b_ri96_1357425334.jpg","width":800,"copyright":"Copyright notice","properties":{"transparent":false,"rtl":false,"export_settings":{"showGrid":true,"showValues":true},"whitelabel":false,"embed_button":"enabled","title_link":"infogram","custom_logo":"infogram","custom_link_url":"","embed_button_text":"Share","decimal_separator":".,"},"elements":[{"type":"particle","particle_id":13161223,"object_id":"d2680fd3-ea32-11e4-a037-7b5f270fdca9","particle_type":"maintitle","picture":null,"text":"Rube Goldberg in the Blood","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":450385,"object_id":"b_ri96_1357425334","particle_type":"quote","picture":null,"text":"\"...the Rube Goldberg machine is irreducibly complex.\"","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"chart","chart_id":686320,"object_id":"b_ri96_1357425413","chart_type_nr":18,"data":[[["","%"],["Rube Goldberg","0.88"],["Irreducibly complex","0.69"],["Blood clotting","0.57"],["Frickin` Thrombin","0.51"],["The Cascade","0.51"],["Stuart Factor","0.42"],["Foghorn Leghorn","0.40"],["Darwin","0.32"],["Fibrinogen","0.27"],["Christmas","0.25"],["Accelerin","0.21"],["Ultra-Complex","0.76"],["Tissue Factor","0.56"],["Yin and Yang BABY","0.53"],["Shufflin` Around","0.27"]]],"custom":{"rotate":"[0]"},"colors":[],"dimensions":[],"modifier":0,"sheetnames":[],"sheets_settings":[]},{"type":"particle","particle_id":378406,"object_id":"b_ri961357428299","particle_type":"quote","picture":null,"text":"\"...the blood-clotting system is called a cascade- a system where one component activates another component, which activates a third component, and so on.\"","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":456208,"object_id":"b_ri961357663116","particle_type":"bodytitle","picture":null,"text":"Saturday Morning Cartoons","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456214,"object_id":"b_ri961357663207","particle_type":"bodytext","picture":null,"text":"Michael J. Behe relates the idea of blood clotting to Rube Goldberg&#39;s machine and the Saturday morning cartoon of Foghorn Leghorn.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456220,"object_id":"b_ri961357663254","particle_type":"bodytext","picture":null,"text":"In the cartoon, Foghorn Leghorn, he was walking along and then he started a Rube Goldberg machine, where he would activate one component after the other. The same goes with blood-clotting. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462826,"object_id":"b_ri961357835592","particle_type":"image","picture":"http://s3-eu-west-1.amazonaws.com/infogram-particles-700/b_ri961357835592.png"},{"type":"particle","particle_id":456229,"object_id":"b_ri961357663407","particle_type":"bodytitle","picture":null,"text":"Of milk cartons and cut fingers","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456239,"object_id":"b_ri961357663481","particle_type":"quote","picture":null,"text":"The landing of an airplane is just one example of a system that has to work within very tight restrictions to avoid disaster.","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":456248,"object_id":"b_ri961357663703","particle_type":"bodytext","picture":null,"text":"In the quote above, Behe gives the example of an airplane to show the little room for error, that our bodies give us for blood clotting.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456262,"object_id":"b_ri961357663842","particle_type":"bodytitle","picture":null,"text":"Patchwork","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456192,"object_id":"b_ri961357663930","particle_type":"bodytext","picture":null,"text":"Fibrinogen breaks from its original structure to form a mesh which blocks the bigger red blood cells from getting out, and then it eventually heals. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456275,"object_id":"b_ri961357664060","particle_type":"bodytext","picture":null,"text":"One might be able to understand the principles of Fibronogen better, when it is compared to a fishing net, and how it is able to keep fish from getting out, and it catches them.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456280,"object_id":"b_ri961357664156","particle_type":"bodytext","picture":null,"text":"Thrombin cuts the peices of fibrinogen which allows it to stick together to make the mesh, and then the fibrinogen turns into fibrin. This has to be regulated though, because if therer is too much fibrin, our blood solidifies and we are deceased.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456285,"object_id":"b_ri961357664294","particle_type":"bodytitle","picture":null,"text":"The cascade","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456293,"object_id":"b_ri961357664307","particle_type":"bodytext","picture":null,"text":"Thrombin when inactive is called prothrombin. The Stuart factor is one of the enzymes that activates prothrombin, thus allowing the blood to clot.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456314,"object_id":"b_ri961357664765","particle_type":"bodytext","picture":null,"text":"Accelerin is another oneof the enzymes, and is the key factor in the reaction that creates thrombin, therefore Stuart with Accelerin activates Thrombin.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456318,"object_id":"b_ri961357664923","particle_type":"quote","picture":null,"text":"Thrombin regulating the production of Accelerin is like having the grandaughter regulate production of the grandmother.","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":456283,"object_id":"b_ri961357664861","particle_type":"bodytext","picture":null,"text":"This is when we run into a BIG problem. Accelerin is initially inactive, but what activates it is Thrombin. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":454315,"object_id":"b_ri961357665078","particle_type":"bodytext","picture":null,"text":"Stuart factor is always cutting prothrombin. Therefore there is always a small amount of Thrombin in the blood stream. This activates the Accelerin, thus producing more Thrombin, making the system auto-catalytic.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456345,"object_id":"b_ri961357665405","particle_type":"bodytext","picture":null,"text":"Prothrombin is not activated just by Thrombin and Accelerin but in the presence of the Amino Acid glutamate, it changes to a y-carboxyglutamate structure, thus being ready to be activated by Accelerin and Stuart Factor.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456354,"object_id":"b_ri961357665502","particle_type":"bodytext","picture":null,"text":"Vitamin K is the last factor in the production of Thrombin. It gives energy to the process above.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456358,"object_id":"b_ri961357665564","particle_type":"bodytitle","picture":null,"text":"Similarities and Differences","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456364,"object_id":"b_ri961357665831","particle_type":"quote","picture":null,"text":"There are some conceptual differences between Foghorn Leghorn&#39;s cartoon contraption and the real-life blood clotting system.","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":456367,"object_id":"b_ri961357665890","particle_type":"bodytext","picture":null,"text":"The most important contrast is that the clotting has to be turned off at some point. The second difference is that there is no clear indicator of who initiates the blood-clotting system.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456372,"object_id":"b_ri961357666092","particle_type":"bodytext","picture":null,"text":"The similarities between the two, is that they are both irriducibly complex.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":456375,"object_id":"b_ri961357666168","particle_type":"bodytext","picture":null,"text":"This process is like a circle. You don&#39;t know where it begins. But if one piece is taken out, then the the whole thing stops working, therefore it is not a circle anymore, making blood-clotting irriducibly complex.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462647,"object_id":"b_ri961357835870","particle_type":"bodytitle","picture":null,"text":"It&#39;s Not over yet","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462852,"object_id":"b_ri961357836014","particle_type":"bodytext","picture":null,"text":"First a plasma protein called antithrombin binds to the active forms of most clotting proteins and inactivates them. Antithrombin is relatively inactive until it bonds with heparin and heparin is present in most undamaged blood vessels.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462868,"object_id":"b_ri961357836184","particle_type":"bodytext","picture":null,"text":"Protein C is the second way that our body finds blood clots. After activating thrombin it elimantes accelerin and activates the antihemophilic factor. Thrombomodulin binds to thrombin which in turn makes it more difficult to cut fibrinogen and simultaneously activating Protein C.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462897,"object_id":"b_ri961357836804","particle_type":"bodytext","picture":null,"text":"Aggragated Fibrin gets tied together with a protein called Fibrin Stabalizing Factor or FSF and it connects different fibrin molecules together. When a protein called plasmin works to cut up fibrin clots but not fibrinogen it can&#39;t occur too quickly because the wound will not have enough time to heal. So it lays in an inactive state called plasinogen.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462961,"object_id":"b_ri961357837424","particle_type":"bodytext","picture":null,"text":" Plasminogen gets converted to plasmin through a protein called t-PA. Blood clotting relies on timing and speed and must be precise for the whole process to run smoothly. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462973,"object_id":"b_ri961357837572","particle_type":"bodytitle","picture":null,"text":" Shufflin&#39; Around ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":462939,"object_id":"b_ri961357837666","particle_type":"quote","picture":null,"text":"Is is possible that this ultra-complex system could have evolved according to Darwinian theory?","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":462992,"object_id":"b_ri961357838253","particle_type":"bodytext","picture":null,"text":"In the past proteins would duplicate themselve and independently acquire change. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463021,"object_id":"b_ri961357838474","particle_type":"bodytitle","picture":null,"text":"The state of the art","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463020,"object_id":"b_ri961357838470","particle_type":"bodytext","picture":null,"text":"The whole process of blood-clotting can be analyzed by comparing it to Yin and Yang through the different steps such as marriage and divorce. ","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463049,"object_id":"b_ri961357839073","particle_type":"image","picture":"http://s3-eu-west-1.amazonaws.com/infogram-particles-700/b_ri961357839073.jpg"},{"type":"particle","particle_id":463052,"object_id":"b_ri961357839097","particle_type":"bodytitle","picture":null,"text":"How&#39;s that again?","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463132,"object_id":"b_ri961357840171","particle_type":"quote","picture":null,"text":"The fact is, no one on Earth has the vaguest idea how the coagulation cascade came to be.","content_type":"","title":"Michael J. Behe","shrink":null},{"type":"particle","particle_id":463092,"object_id":"b_ri961357839674","particle_type":"bodytext","picture":null,"text":"Evolution theorizes that blood clotting was randomized by the shuffling of genes, the probability of shuffled genes chance of this happening is 1/10 to the 18th power. This just goes to show how the theory of blood clotting evolved.","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463149,"object_id":"b_ri961357840335","particle_type":"bodytitle","picture":null,"text":"APplause, Applause","content_type":"","title":null,"shrink":null},{"type":"particle","particle_id":463151,"object_id":"b_ri961357840368","particle_type":"bodytext","picture":null,"text":"The process of blood clotting, is in turn, almost identical to that of a Rube Goldberg machine, in the way that it is arranged and the sequence of events.","content_type":"","title":null,"shrink":null}],"theme":{"createdAt":"2016-04-22T04:54:06.000Z","updatedAt":"2016-12-28T10:32:26.000Z","logoImages":[""],"charts":{"treemap":{"labels":{"name":{"fontFamily":"PT Sans Narrow","fontWeight":"700"},"value":{"fontFamily":"PT Sans 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